Professor Yao Ke of the eye hospital of Zhejiang University, researcher Zhou Min of the school of translational medicine of Zhejiang University and other teams, A new method based on induced pluripotent stem cell derived mesenchymal stem cells secreted exocrine (iPSC-MSC-Exos) and thermosensitive chitosan / gelatin hydrogel materials was developed for the treatment of corneal trauma. It can significantly reduce corneal scar formation and accelerate healing process, and provide new ideas for the treatment of corneal diseases.
Corneal injury forms scar tissue and shows permanent corneal opacity, which is the main cause of visual impairment caused by corneal diseases. Because of its low regenerative ability, it is one of the most serious blindness diseases in clinic.
Aiming at the key scientific problem of scar repair after corneal injury, Professor Yao Ke's team and Professor Zhou Min's team decided to start with the molecular mechanism of corneal scar and combined with the research progress of new biomaterials, A new method based on induced pluripotent stem cell derived exudate (iPSC-MSC-Exos) secreted by mesenchymal stem cells (MSCs) and thermosensitive chitosan / gelatin hydrogels was developed.
Professor Yao Ke
This study shows that thermosensitive chitosan gel sustained release iPSC-MSC-Exos can effectively promote the repair of damaged corneal epithelium and stromal layer, downregulate the expression of collagen in corneal stroma, and reduce scar formation in vivo. Moreover, the molecular mechanism of scar repair after corneal injury was further revealed. It provides a new treatment for clinical corneal diseases, which has great potential for clinical application and transformation.
The article "exosomes loaded thermosensive hydrogels for coral Egypt and strategy regeneration" has been published in the international top journal in the field of biomaterials and the international first-class journal in the field of engineering technology "biomaterials" (top journal in zone 1 of Chinese Academy of Sciences, if: 12.479)